Section: New Results

Species Minimization in Biochemical Reaction Computing

Participants : Hui-Ju Chiang, François Fages.

Engineering biochemical reactions for computational purposes is a common pursue in synthetic biology. In such design tasks, molecular species have to be carefully engineered to ensure modularity and orthogonality, and are scarce resources. Minimizing the number of involved molecular species is crucial to accomplish a complex computation within a confined biochemical environment.

In [10] , we investigate an approach to species minimization by reusing modular and regular reactions in an asynchronous time-multiplexed fashion. Our method enhances not only species utility, but also re-programmability and robustness in realizing various logic circuits. A case study demonstrates the ease of design in realizing general logic computation, and simulation confirms the feasibility and robustness of the proposed method.

This work is done in collaboration with Jie-Hong Jiang and Katherine Chiang from NTU Taiwan in the context of a common project about biochemical programming.